JWH-018 is a synthetic cannabinoid found in several versions of the herbal mixture “Spice.” While considerably more potent than similar amounts of cannabis, JWH-018 also presents significant challenges for detection by typical Δ9-THC testing assays.
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JWH-018 (1-Pentyl-3-(1-naphthoyl)indole) is a synthetic cannabinoid and a member of the naphthoylindole family. Known for its affinity to CB1 and CB2 receptors, it has been widely used in pharmacological research to explore cannabinoid receptor behavior, signal transduction, and analog binding properties.
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