AMT (α-Methyltryptamine)

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AMT is a designer drug from the substituted tryptamine family, known for its stimulant and psychedelic properties. If you’re searching for high-purity AMT, avoid unreliable sources. Instead, buy AMT research chemical online from a reputable vendor like buy-pure-chemicals.com to ensure safety, purity, and consistency in your research compound. Don’t take chances—buy AMT research chemical online with confidence.

α-Methyltryptamine for Sale Online – Buy AMT Research Chemical

α-Methyltryptamine (αMT, AMT) is a potent psychedelic, stimulant, and entactogen that belongs to the tryptamine class. Initially developed as an antidepressant by Upjohn in the 1960s, it was briefly marketed in Russia under the name Indopan before being discontinued. Today, AMT remains widely researched for its unique pharmacological properties.

Chemistry

αMT is a modified version of tryptamine with a methyl group at the alpha carbon. This modification prevents quick breakdown by monoamine oxidase A (MAO-A), increasing its half-life and allowing it to cross the blood-brain barrier effectively. Its chemical relationship to serotonin (5-hydroxytryptamine) partly explains its psychoactive effects. The structural relationship between αMT and tryptamine is similar to that of amphetamine and phenethylamine, making it a tryptamine analog with extended action.

Synthesis

The synthesis of AMT can be achieved through multiple routes. The two most common methods include:

• Nitroaldol Condensation: A reaction between indole-3-carboxaldehyde and nitroethane using ammonium acetate as a catalyst.
• Keto-Oxime Reduction: A condensation between indole-3-acetone and hydroxylamine, followed by reduction of the ketoxime using lithium aluminum hydride.

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Pharmacology

AMT functions as a balanced reuptake inhibitor and releasing agent for serotonin, norepinephrine, and dopamine, making it a powerful monoaminergic agent. Additionally, it acts as a non-selective serotonin receptor agonist, giving it both stimulant and psychedelic effects. Its unique mechanism of action makes it valuable for neurochemical and behavioral studies.

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