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| Substance | Therapeutic Use in Mental Health | Status |
|---|---|---|
| PsilocybinΒ (magic mushrooms) | Depression, anxiety, PTSD, addiction | Clinical trials; FDA “Breakthrough Therapy” designation |
| MDMAΒ (Ecstasy) | PTSD (especially treatment-resistant) | Advanced clinical trials (Phase 3); under FDA review |
| KetamineΒ (and esketamine) | Treatment-resistant depression, suicidal ideation | FDA-approved for depression (esketamine via nasal spray) |
| Cannabis/THC/CBD | Anxiety, PTSD, psychosis adjunct, chronic pain | Legalized or decriminalized in some areas; studied for psychiatric use |
Note: These are usedΒ in clinical or research settings, not as “recreational” drugs.
Β 2. Recreational Use in Mental Hospitals
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